BiologicalActivity
Potentandselective5-HT7receptorantagonist(pKivaluesare8.9,7.2and6.0for5-HT7A,5-HT5Aand5-HT1Band<6.0for5-HT1A,5-HT1D,5-HT1E,5-HT1F,5-HT2A,5-HT2B,5-HT2C,5-HT4and5-HT6receptorsrespectively).Brainpenetrantinvivo.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline.
CompoundLibraries
SB269970hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 388.95 |
| Formula | C18H28N2O3S.HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 261901-57-9 |
| PubChemID | 11957684 |
| InChIKey | XQCJOYZLWFNDIO-PKLMIRHRSA-N |
| Smiles | OC1=CC(S(N2[C@@H](CCN3CCC(C)CC3)CCC2)(=O)=O)=CC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| phosphatebufferedsaline | 1.76 | 5 | |
| DMSO | 38.89 | 100 | |
| water | 7.78 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight388.95.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.86mL | 25.71mL |
| 5mM | 0.51mL | 2.57mL | 5.14mL |
| 10mM | 0.26mL | 1.29mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
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