BiologicalActivity
PotentandselectiveCCR3antagonist(IC50=4nM).Displays>2500-foldselectivityoverC5aR,LTD4,CCR7,CXCR1andCXCR2receptors.Inhibitseotaxin-,eotaxin-2-andMCP-4-inducedCa2+mobilization(IC50valuesare38,35and20nMrespectively)andinhibitseotaxin-,eotaxin-2-andMCP-4-inducedeosinophilchemotaxiswithsimilarpotencies.
CompoundLibraries
SB328437isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 378.38 |
| Formula | C21H18N2O5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 247580-43-4 |
| PubChemID | 10474776 |
| InChIKey | VMFGCGRAIBLAFY-IBGZPJMESA-N |
| Smiles | O=C(C2=CC=CC3=C2C=CC=C3)N[C@H](C(OC)=O)CC1=CC=C([N+]([O-])=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.84 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight378.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.64mL | 13.21mL | 26.43mL |
| 5mM | 0.53mL | 2.64mL | 5.29mL |
| 10mM | 0.26mL | 1.32mL | 2.64mL |
| 50mM | 0.05mL | 0.26mL | 0.53mL |
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