BiologicalActivity
PotentCXCR2antagonist(IC50=7.7nM).Exhibits285-foldselectivityforCXCR2overCXCR1.Reducesleukocytenumbersinsynovialfluidinacuteandchronicrabbitarthritismodels.Alsoreducessynovialfluideicosanoidandcytokinelevelsinarabbitchronicarthritismodel.InhibitsproliferationofAMLcelllinesinvitro.
TechnicalData
| M.Wt | 410.66 |
| Formula | C13H10Cl3N3O4S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 276702-15-9 |
| PubChemID | 9887803 |
| InChIKey | WTLRWOHEKQGKDS-UHFFFAOYSA-N |
| Smiles | ClC1=C(S(=O)(N)=O)C(O)=C(NC(NC2=C(Cl)C(Cl)=CC=C2)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.07 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight410.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.44mL | 12.18mL | 24.35mL |
| 5mM | 0.49mL | 2.44mL | 4.87mL |
| 10mM | 0.24mL | 1.22mL | 2.44mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
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