BiologicalActivity
Selectivenon-peptideorexinOX1receptorantagonist.pKbvaluesare7.2and<5forinhibitionofintracellularCa2+releaseinCHOcellsexpressinghumanOX1andOX2receptorsrespectively.Blocksorexin-Ainducedgroomingandfeedingfollowingsystemicadministrationinvivo.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
SB334867isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 319.32 |
| Formula | C17H13N5O2 |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 792173-99-0 |
| PubChemID | 6604926 |
| InChIKey | AKMNUCBQGHFICM-UHFFFAOYSA-N |
| Smiles | CC1=NC2=CC=C(NC(=O)NC3=CC=NC4=CC=CN=C34)C=C2O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.93 | 100mMwithgentlewarming | |
| ethanol | 3.19 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight319.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.13mL | 15.66mL | 31.32mL |
| 5mM | 0.63mL | 3.13mL | 6.26mL |
| 10mM | 0.31mL | 1.57mL | 3.13mL |
| 50mM | 0.06mL | 0.31mL | 0.63mL |
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