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Description:Potentandselective5-HT6antagoNIST
ChemicalName:N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamidehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potent,brainpenetrant,orallyactive5-HT6antagonist.Displays>200-foldselectivityfor5-HT6overother5-HTreceptors(pKivaluesare9.11,8.81and9.02 forhumanrecombinant,nativeratandnativehuman5-HT6receptorsrespectively).
CompoundLibraries
SB399885hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 482.81 |
| Formula | C18H21Cl2N3O4S.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 402713-81-9 |
| PubChemID | 6918649 |
| InChIKey | ATKZKAYWARYLBW-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=CC(Cl)=CC(NS(C2=CC(N3CCNCC3)=C(OC)C=C2)(=O)=O)=C1OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.28 | 100 | |
| water | 48.28 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight482.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.07mL | 10.36mL | 20.71mL |
| 5mM | 0.41mL | 2.07mL | 4.14mL |
| 10mM | 0.21mL | 1.04mL | 2.07mL |
| 50mM | 0.04mL | 0.21mL | 0.41mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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