BiologicalActivity
Potent,selectivenon-peptidePAR1receptorantagonist(IC50=70nM).InhibitshaTRAP-induced-butnotγ-thrombin-,ADP-orcollagen-inducedhumanplateletaggregation.AlsoselectivelyblocksPAR1agonist-orthrombin-inducedincreasesincytosolicCa2+invascularsmoothmusclecells.
TechnicalData
| M.Wt | 444.41 |
| Formula | C23H25N5.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1216720-69-2 |
| PubChemID | 45073452 |
| InChIKey | NNJTXSQXGHYXAJ-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CC(C)C1=CC=C(CN2C=CC3=C2C=CC2=NC(NC4CC4)=NC(N)=C32)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.22 | 50 | |
| ethanol | 11.11 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight444.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.25mL | 11.25mL | 22.5mL |
| 5mM | 0.45mL | 2.25mL | 4.5mL |
| 10mM | 0.23mL | 1.13mL | 2.25mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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