BiologicalActivity
PotentandselectiveCB1receptorantagonist(Ki=7.8nM).Exhibits1000-foldselectivityforCB1overCB2receptors.InhibitsCP55,940-inducedhypotensionandWIN55,212-2-inducedhypothermiainvivo.Orallyactive.
CompoundLibraries
(±)-SLV319isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 487.4 |
| Formula | C23H20Cl2N4O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 362519-49-1 |
| PubChemID | 11179267 |
| InChIKey | AXJQVVLKUYCICH-UHFFFAOYSA-N |
| Smiles | ClC(C=C4)=CC=C4C1=NN(/C(NS(C3=CC=C(Cl)C=C3)(=O)=O)=NC)CC1C2=CC=CC=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.74 | 100 | |
| ethanol | 4.87 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight487.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.05mL | 10.26mL | 20.52mL |
| 5mM | 0.41mL | 2.05mL | 4.1mL |
| 10mM | 0.21mL | 1.03mL | 2.05mL |
| 50mM | 0.04mL | 0.21mL | 0.41mL |
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