BiologicalActivity
PotentandselectiveadenosineA1receptorantagonist(Kivaluesare1,200,398and3981nMathumanA1,A3,A2AandA2Breceptorsrespectively).Suppressescardiacfibrosisandattenuatesalbuminuria,withouteffectonbloodpressureinanimalmodelsofchronicrenalfailure.Orallyactive.
TechnicalData
| M.Wt | 308.38 |
| Formula | C18H20N4O |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 251945-92-3 |
| PubChemID | 9953065 |
| InChIKey | RBZNJGHIKXAKQE-UHFFFAOYSA-N |
| Smiles | O[C@@H](CC4)CC[C@H]4NC1=C2C(NC=C2)=NC(C3=CC=CC=C3)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.84 | 100 | |
| ethanol | 15.42 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight308.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.24mL | 16.21mL | 32.43mL |
| 5mM | 0.65mL | 3.24mL | 6.49mL |
| 10mM | 0.32mL | 1.62mL | 3.24mL |
| 50mM | 0.06mL | 0.32mL | 0.65mL |
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