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Description:PregnaneXreceptoragoNIST
ChemicalName:[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PregnaneXreceptor(PXR)agonist(EC50valuesare200and700nMforhumanandrabbitPXRrespectively).ActivatesthefarnesoidXreceptor(FXR)atμMconcentrations.DisplayshypocholesterolaemicactivityviaenchanceddegradationofHMG-CoAreductase.
TechnicalData
M.Wt | 504.53 |
Formula | C24H42O7P2 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 126411-39-0 |
PubChemID | 446313 |
InChIKey | YQLJDECYQDRSBI-UHFFFAOYSA-N |
Smiles | OC1=C(C(C)(C)C)C=C(/C=C(P(OCC)(OCC)=O)/P(OCC)(OCC)=O)C=C1C(C)(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 50.45 | 100 | |
ethanol | 50.45 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight504.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.98mL | 9.91mL | 19.82mL |
5mM | 0.4mL | 1.98mL | 3.96mL |
10mM | 0.2mL | 0.99mL | 1.98mL |
50mM | 0.04mL | 0.2mL | 0.4mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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