Tocris试剂产品信息 Tocris Bioscience批发，产品货源,Tocris/SR 2211/4869/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/SR 2211/4869/10/10 mg

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Tocris

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4869/10

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Description:SelectiveRORγinverseagoNIST

ChemicalName:2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveinverseagonistofretinoicacidreceptor-relatedorphanreceptorγ(RORγ)(K_i=105nM;IC₅₀~320nM).ExhibitsweakactivityatliverXreceptorα(LXRα);doesnotaffectthetranscriptionalactivityoffarnesoidXreceptors(FXR),andhasnoimpactonthetranscriptionalactivityofRORα.

LicensingInformation

SoldunderlicensefromTheScrippsResearchInstitute.

CompoundLibraries

SR2211isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	527.48
Formula	C₂₆H₂₄F₇N₃O
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1359164-11-6
PubChemID	51035449
InChIKey	KVHKWAZUPPBMLL-UHFFFAOYSA-N
Smiles	FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	26.37	50
	DMSO	52.75	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight527.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.9mL	9.48mL	18.96mL
5mM	0.38mL	1.9mL	3.79mL
10mM	0.19mL	0.95mL	1.9mL
50mM	0.04mL	0.19mL	0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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