BiologicalActivity
Potent,non-peptideCCK1receptorantagonistthatdisplays>33-foldselectivityoverCCK2receptors(EC50valuesare6and200nMrespectively).Causesanincreaseinplasmaleptinlevelsandincreasesfoodintakeinratsinvivo.
CompoundLibraries
SR27897isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 411.86 |
| Formula | C20H14ClN3O3S |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 136381-85-6 |
| PubChemID | 122077 |
| InChIKey | ILNRQFBVVQUOLP-UHFFFAOYSA-N |
| Smiles | OC(=O)CN1C(=CC2=CC=CC=C12)C(=O)NC1=NC(=CS1)C1=CC=CC=C1Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.59 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight411.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.43mL | 12.14mL | 24.28mL |
| 5mM | 0.49mL | 2.43mL | 4.86mL |
| 10mM | 0.24mL | 1.21mL | 2.43mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
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