Tocris离子通道调控剂 Tocris配体,Tocris/SR 48692/3721/50/50 mg,受体,Tocris,Bio-Techne,,50 mg蚂蚁淘商城

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Tocris/SR 48692/3721/50/50 mg

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Tocris

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3721/50

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Description:Selectivenon-peptideNTS₁antagoNIST

ChemicalName:2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Neurotensinantagonist;selectiveforNTS₁overNTS₂(apparentaffinity,K_e,is36nMforNTS₁).Competitivelyinhibitsbindingof[¹²⁵I]-neurotensintoHT29andN1E115cellmembranes(IC₅₀valuesare15.3and20.4nMrespectively).Orallybioavailable.

TechnicalData

M.Wt	587.07
Formula	C₃₂H₃₁ClN₄O₅
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	146362-70-1
PubChemID	119192
InChIKey	DYLJVOXRWLXDIG-UHFFFAOYSA-N
Smiles	O=C(NC5(C(O)=O)C4CC(CC5C6)CC6C4)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C7)C7=NC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	11.74	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight587.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.7mL	8.52mL	17.03mL
5mM	0.34mL	1.7mL	3.41mL
10mM	0.17mL	0.85mL	1.7mL
50mM	0.03mL	0.17mL	0.34mL

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