BiologicalActivity
Rev-Erbαantagonist;inhibitsRev-Erbαtranscriptionalrepression(EC50=0.47μM).BlocksactivityofRev-ErbαagonistGSK4112(Cat.No.3663)inHEK293cells.Increasesexpressionofglucose-regulatinggenes,G6PaseandPEPCKinHepG2cells.
TechnicalData
| M.Wt | 361.48 |
| Formula | C18H19NO3S2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1254944-66-5 |
| PubChemID | 53393127 |
| InChIKey | UIEBLUZPSFAFOC-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C1=CC=C(SC)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.15 | 100 | |
| ethanol | 18.07 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight361.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.83mL | 27.66mL |
| 5mM | 0.55mL | 2.77mL | 5.53mL |
| 10mM | 0.28mL | 1.38mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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