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Description:SelectiveNK1antagoNIST
AlternativeNames:[D-Arg1,D-Trp7,9,Leu11]-SubstanceP
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectiveNK1receptorantagonist(Kivaluesare230,8150and>10000nMforratNK1,NK2andNK3receptorsrespectively).Activeinvivo.
TechnicalData
| M.Wt | 1497.8 |
| Formula | C75H108N20O13 |
| Sequence | RPKPQQWFWLL (Modifications:Arg-1=D-Arg,Trp-7=Trp-9=D-Trp) |
| Storage | Desiccateat-20°C |
| CASNumber | 91224-37-2 |
| PubChemID | 25079075 |
| InChIKey | SAPCBHPQLCZCDV-CHPWDEGWSA-N |
| Smiles | [H]N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1497.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.67mL | 3.34mL | 6.68mL |
| 5mM | 0.13mL | 0.67mL | 1.34mL |
| 10mM | 0.07mL | 0.33mL | 0.67mL |
| 50mM | 0.01mL | 0.07mL | 0.13mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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