中国Tocris公司 Tocris Bioscience现货代理,Tocris/Stressin I/1608/500U/500 ug,受体,Tocris,Bio-Techne,,500 ug蚂蚁淘商城

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Tocris/Stressin I/1608/500U/500 ug

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Tocris

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1608/500U

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4000-520-616

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Description:CRF₁agoNIST

AlternativeNames:cyclo(31-34)[D-Phe¹²,Nle^21,38,Glu³¹,Lys³⁴]Ac-hCRF(4-41)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivecorticotropinreleasingfactorreceptor-1(CRF₁)agonist(K_ivaluesare1.5and224nMforCRF₁andCRF₂receptorsrespectively).IncreasesACTHlevelsandincreasesfaecalpelletoutputinvivofollowingi.p.administration.

LicensingInformation

SoldwiththepermissionoftheSALKInstitute

TechnicalData

M.Wt	4472.24
Formula	C₂₀₃H₃₃₇N₅₇O₅₆
Sequence	PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII (Modifications:Pro-1=N-terminalAc,X=Nle,Glu-28=γ-Glu,Lys-31=ε-Lys,Cyclized=Glu-28-Lys-31,Ile-38=C-terminalamide)
Storage	Desiccateat-20°C
PubChemID	90479815
InChIKey	HZKFMBAUDWRPRY-WNBAZHKDSA-N
Smiles	CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	Solubleto1mg/mlinwater

Solubility

Solubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4472.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.22mL	1.12mL	2.24mL
5mM	0.04mL	0.22mL	0.45mL
10mM	0.02mL	0.11mL	0.22mL
50mM	0mL	0.02mL	0.04mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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