Tocris报价单 Tocris抗体,Tocris/T 98475/2519/1/1 mg,受体,Tocris,Bio-Techne,,1 mg蚂蚁淘商城

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Tocris/T 98475/2519/1/1 mg

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Tocris

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2519/1

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Description:GnRHreceptorantagoNIST

ChemicalName:7-[(2,6-Difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-thieno[2,3-b]pyridine-5-carboxylicacid1-methylethylester

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,orallyactiveandnon-peptidegonadotropin-releasinghormone(GnRH,LHRH)receptorantagonist(IC₅₀valuesare0.2,4.0and60nMforhuman,monkeyandratGnRHreceptorsrespectively).InhibitsLHreleaseinvitro(IC₅₀=100nM)andreducesplasmaLHconcentrationincastratedmalecynomolgusmonkeys.

TechnicalData

M.Wt	657.77
Formula	C₃₇H₃₇F₂N₃O₄S
Storage	Desiccateat+4°C
Purity	≥98%(HPLC)
CASNumber	199119-18-1
PubChemID	9874838
InChIKey	RANJJVIMTOIWIN-UHFFFAOYSA-N
Smiles	CC(C)OC(=O)C1=CN(CC2=C(F)C=CC=C2F)C2=C(C(CN(C)CC3=CC=CC=C3)=C(S2)C2=CC=C(NC(=O)C(C)C)C=C2)C1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	32.89	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight657.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.52mL	7.6mL	15.2mL
5mM	0.3mL	1.52mL	3.04mL
10mM	0.15mL	0.76mL	1.52mL
50mM	0.03mL	0.15mL	0.3mL

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