BiologicalActivity
Potentandselectivesphingosine-1-phosphatereceptor1(S1P1)agonist(EC50=35nM),displays>100-foldselectivityagainstreceptorsubtypesS1P2-5.Inducesadose-dependentreductionincirculatingbloodlymphocytecountsinrodentmodels.Orallybioavailable.
CompoundLibraries
TC-G1006isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 415.37 |
| Formula | C21H16F3N3O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1324003-64-6 |
| PubChemID | 54764919 |
| InChIKey | MLDQTQOMWDNTNN-UHFFFAOYSA-N |
| Smiles | O=C(NC(C2=C(OC)C=CN=C2)=O)NC1=CC=C(C3=CC=CC=C3)C(C(F)(F)F)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto100mMinDMSO |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight415.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.41mL | 12.04mL | 24.07mL |
| 5mM | 0.48mL | 2.41mL | 4.81mL |
| 10mM | 0.24mL | 1.2mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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