BiologicalActivity
PotentandselectiveGPR39agonist(EC50valuesare0.4and0.8nMforratandhumanreceptorsrespectively).Selectiveoverapanelofkinases(IC50s>10μM)anddisplaysminimalbindingaffinityforghrelinandneurotensin-1receptors(IC50s>30μM).IncreasesGLP-1levelsinvitroandinvivo.Orallybioavailable.
CompoundLibraries
TC-G1008isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 418.9 |
| Formula | C18H19ClN6O2S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1621175-65-2 |
| PubChemID | 91826086 |
| InChIKey | DRSZMILOMUPIBJ-UHFFFAOYSA-N |
| Smiles | CNC1=NC(NCC2=C(Cl)C=C(NS(C)(=O)=O)C=C2)=CC(C3=NC=CC=C3)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.89 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight418.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.39mL | 11.94mL | 23.87mL |
| 5mM | 0.48mL | 2.39mL | 4.77mL |
| 10mM | 0.24mL | 1.19mL | 2.39mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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