BiologicalActivity
Potent,dualorexinreceptorantagonist(Kivaluesare0.2and3nMforOX2andOX1receptorsrespectively).InhibitsADL-orexinB-mediatedlocomotionfollowingi.p.administrationinvivoandblocksorexin-A(Cat.No.1455)mediatedincreasesinfeedingbehaviour.Brainpenetrant.
LicensingInformation
ManufacturedandsoldunderlicensefromMerck&Co.,Inc.forusesolelyforpreclinicalresearchpurposes(ie:notforadministrationtoorotheruseinhumans)
TechnicalData
| M.Wt | 470.59 |
| Formula | C27H26N4O2S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 916141-36-1 |
| PubChemID | 11960895 |
| InChIKey | YSBGRVXJEMSEQY-DEOSSOPVSA-N |
| Smiles | O=C(CSC2=NC(C=CC=C5)=C5N2C)N1CCC[C@H]1[C@](NC3=CC=CC=C3C4=CC=CC=C4)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.06 | 100 | |
| ethanol | 47.06 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight470.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.12mL | 10.62mL | 21.25mL |
| 5mM | 0.42mL | 2.12mL | 4.25mL |
| 10mM | 0.21mL | 1.06mL | 2.12mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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