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Description:α1andα2BantagoNIST(α1>α2B).Orallyactive
ChemicalName:1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazinehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
α1-andα2B-adrenoceptorantagonist(Kivaluesare3.3,0.7,1.1,7.7,1510and78.2nMforα1A,α1B,α1D,α2B,α2Aandα2Creceptorsrespectively).Antihypertensivefollowingoralorintravenousadministrationinvivo.
TechnicalData
| M.Wt | 423.9 |
| Formula | C19H25N5O4.HCl |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 63074-08-8 |
| PubChemID | 44383 |
| InChIKey | IWSWDOUXSCRCKW-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.2 | 50mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight423.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.36mL | 11.8mL | 23.59mL |
| 5mM | 0.47mL | 2.36mL | 4.72mL |
| 10mM | 0.24mL | 1.18mL | 2.36mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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