BiologicalActivity
PotenthistamineH3andH4antagonist/inverseagonist.Kivaluesare25and27nMforhumanrecombinantH3andH4receptorsrespectively.Blockseosinophilshapechange(IC50=1.4μM)andchemotaxis(IC50=519nM)inducedbyhistamine.Freelycrossestheblood-brainbarrier.AlsoavailableaspartoftheHistamineH3ReceptorTocriset™.
CompoundLibraries
ThioperamideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 292.44 |
| Formula | C15H24N4S |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 106243-16-7 |
| PubChemID | 3035905 |
| InChIKey | QKDDJDBFONZGBW-UHFFFAOYSA-N |
| Smiles | S=C(NC3CCCCC3)N(CC2)CCC2C1=CNC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.24 | 100 | |
| ethanol | 29.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight292.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.42mL | 17.1mL | 34.2mL |
| 5mM | 0.68mL | 3.42mL | 6.84mL |
| 10mM | 0.34mL | 1.71mL | 3.42mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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