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Tocris/Troglitazone/3114/50/50 mg

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Tocris

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3114/50

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4000-520-616

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Description:SelectivePPARγagoNIST;antidiabeticagent

AlternativeNames:Rezulin

ChemicalName:5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectivePPARγreceptoragonist(EC₅₀valuesare780and555nMatmurineandhumanPPARγreceptorsrespectively).DisplaysnoactivityatPPARαorPPARδreceptors.Antidiabeticagent;exertspotentglucose-loweringeffectsininsulin-resistantdiabeticmice.Displaysanti-invasiveeffectonhumanbreastcancercells;reducesmigration,adhesionandspreADIngonfibronectin-coatedplates.Alsoinhibitscellgrowthofhematopoieticcelllines.Inhibitslamellipodiaformationandactinpolymerization.

CompoundLibraries

TroglitazoneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	441.54
Formula	C₂₄H₂₇NO₅S
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	97322-87-7
PubChemID	5591
InChIKey	GXPHKUHSUJUWKP-UHFFFAOYSA-N
Smiles	CC1=C2C(CCC(COC3=CC=C(CC4C(NC(S4)=O)=O)C=C3)(C)O2)=C(C)C(O)=C1C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	44.15	100
	ethanol	4.42	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight441.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.26mL	11.32mL	22.65mL
5mM	0.45mL	2.26mL	4.53mL
10mM	0.23mL	1.13mL	2.26mL
50mM	0.05mL	0.23mL	0.45mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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