BiologicalActivity
Potent,selectiveandcompetitivesilentantagonistfortheNOPopioidreceptor.BindstoNOPwithhighaffinity(pKi=10.24)anddisplays>3000-foldselectivityoverδ,μandκopioidreceptors.Antinociceptiveandopposestheactionofnociceptininvivo.
TechnicalData
| M.Wt | 1908.19 |
| Formula | C82H138N32O21 |
| Sequence | GGGFTGARKSARKRKNQ (Modifications:Gly-1=N-(Bn)Gly,Gln-17=C-terminalamide) |
| Storage | Desiccateat-20°C |
| CASNumber | 849024-68-6 |
| PubChemID | 16152632 |
| InChIKey | DOLKPWDXAQZKNJ-LGCGZHPXSA-N |
| Smiles | C[C@@H](O)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)CNCC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1908.19.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.52mL | 2.62mL | 5.24mL |
| 5mM | 0.1mL | 0.52mL | 1.05mL |
| 10mM | 0.05mL | 0.26mL | 0.52mL |
| 50mM | 0.01mL | 0.05mL | 0.1mL |
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