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Description:Toll-likereceptor(TLR)5/FlagellincomplexantagoNIST
ChemicalName:4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Toll-likereceptor(TLR)5/Flagellincomplexantagonist(IC50=0.85μM).CompeteswithflagellinforTLR5bindingtoinhibittheTLR5:flagellininteractionandsubsequentdownstreamTNF-αsecretion.
TechnicalData
M.Wt | 453.54 |
Formula | C23H15N7S2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1841460-82-9 |
PubChemID | 124203921 |
InChIKey | CBBXTGWSGPEJEE-UHFFFAOYSA-N |
Smiles | N1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 2.27 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight453.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.2mL | 11.02mL | 22.05mL |
5mM | 0.44mL | 2.2mL | 4.41mL |
10mM | 0.22mL | 1.1mL | 2.2mL |
50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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