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Description:SelectivepositiveallostericmodulatorofM5receptors
ChemicalName:1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectivepositiveallostericmodulatorofM5receptors(EC50valuesare1.16,>30and>30μMatM5,M1andM3receptorsrespectively).DisplaysnoactivityatM2andM4receptors.
CompoundLibraries
VU0238429isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 351.28 |
Formula | C17H12F3NO4 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1160247-92-6 |
PubChemID | 42633508 |
InChIKey | CKLGZXFOLMHCMC-UHFFFAOYSA-N |
Smiles | O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(OC)C=C3)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 35.13 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight351.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.85mL | 14.23mL | 28.47mL |
5mM | 0.57mL | 2.85mL | 5.69mL |
10mM | 0.28mL | 1.42mL | 2.85mL |
50mM | 0.06mL | 0.28mL | 0.57mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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