BiologicalActivity
NegativeallostericmodulatorofmGlu5receptors.DisplayshighaffinityfortheMPEP(Cat.No.1212)bindingsite;actsasafullantagoNISTandblockstheglutamateresponsetomGlu5(IC50=24.4nM).SelectiveformGlu5overmGlu1,mGlu3andmGlu4.Exhibitsanxiolyticactivityinrodentmodelsofanxiety.Analogavailable(Cat.No.4323).
TechnicalData
| M.Wt | 266.23 |
| Formula | C14H7FN4O |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 327056-22-4 |
| PubChemID | 9816778 |
| InChIKey | GELAFISMURFRCA-UHFFFAOYSA-N |
| Smiles | FC1=CC(C#N)=CC(C2=NC(C3=NC=CC=C3)=NO2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.31 | 50 | |
| ethanol | 6.66 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight266.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.76mL | 18.78mL | 37.56mL |
| 5mM | 0.75mL | 3.76mL | 7.51mL |
| 10mM | 0.38mL | 1.88mL | 3.76mL |
| 50mM | 0.08mL | 0.38mL | 0.75mL |
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