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Description:PositiveallostericmodulatorofM5receptors
ChemicalName:1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectivepositiveallostericmodulatorofM5(EC50valuesare2.7μMforhumanM5,and>30μMforM1,M2,M3andM4receptors).
TechnicalData
M.Wt | 397.35 |
Formula | C22H14F3NO3 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1208222-39-2 |
PubChemID | 45281794 |
InChIKey | SPBGRXOPAXZSER-UHFFFAOYSA-N |
Smiles | O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(C4=CC=CC=C4)C=C3)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.73 | 100 | |
ethanol | 3.97 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight397.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.52mL | 12.58mL | 25.17mL |
5mM | 0.5mL | 2.52mL | 5.03mL |
10mM | 0.25mL | 1.26mL | 2.52mL |
50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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