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Description:PositiveallostericmodulatorofM5receptors
ChemicalName:1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectivepositiveallostericmodulatorofM5(EC50valuesare2.7μMforhumanM5,and>30μMforM1,M2,M3andM4receptors).
TechnicalData
| M.Wt | 397.35 |
| Formula | C22H14F3NO3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1208222-39-2 |
| PubChemID | 45281794 |
| InChIKey | SPBGRXOPAXZSER-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(C4=CC=CC=C4)C=C3)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.73 | 100 | |
| ethanol | 3.97 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight397.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.58mL | 25.17mL |
| 5mM | 0.5mL | 2.52mL | 5.03mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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