BiologicalActivity
CaSRbiasedallostericmodulator(pEC50=7.8-8.1).Calcimimetic.DisplaysABIlitytobiassignallingtowardstheaccumulationofPERK1/2andIP1.Reducesparathyroidhormone(PTH)levelsinratserumwithoutinducingthereleaseofcalcitonin.ExhibitsnosignificantactivationofhumanGABABortypeIPTHreceptors.Orallyactive.
TechnicalData
| M.Wt | 283.39 |
| Formula | C17H17NOS |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1253901-26-6 |
| PubChemID | 52943938 |
| InChIKey | IGSZVEPQZANNAB-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=C(C(O)(C2=NC3=CC=CC=C3S2)C)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.34 | 100 | |
| ethanol | 28.34 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight283.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.53mL | 17.64mL | 35.29mL |
| 5mM | 0.71mL | 3.53mL | 7.06mL |
| 10mM | 0.35mL | 1.76mL | 3.53mL |
| 50mM | 0.07mL | 0.35mL | 0.71mL |
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