Tocris代理，产品目录中国Tocris Bioscience公司,Tocris/XCT 790/3928/10/10 mg,受体,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/XCT 790/3928/10/10 mg

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Tocris

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3928/10

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Description:SelectiveERRαantagoNIST/inverseagonist

ChemicalName:3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiADIazol-2-yl)acrylamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveERRαantagonist/inverseagonist(IC₅₀=~400nM).DisplaysnoantagonistactivityatERRγorERαatconcentrationsbelow10μM.InterfereswithPPARγcoactivator-1α(PGC-1α)/ERRα-dependentsignaling:inhibitsPGC-1αinductionofERRαandMAO-BgeneexpressionanddownregulatestheconstitutivetranscriptionalactivityofERRαinnumerouscelllines.

TechnicalData

M.Wt	596.42
Formula	C₂₃H₁₃F₉N₄O₃S
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	725247-18-7
PubChemID	6918788
InChIKey	HQFNFOOGGLSBBT-AWNIVKPZSA-N
Smiles	O=C(NC3=NN=C(C(F)(F)F)S3)/C(C#N)=C/C(C=C2OC)=CC=C2OCC1=C(C(F)(F)F)C=C(C(F)(F)F)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	5.96	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight596.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.68mL	8.38mL	16.77mL
5mM	0.34mL	1.68mL	3.35mL
10mM	0.17mL	0.84mL	1.68mL
50mM	0.03mL	0.17mL	0.34mL

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