BiologicalActivity
SelectiveERRαantagonist/inverseagonist(IC50=~400nM).DisplaysnoantagonistactivityatERRγorERαatconcentrationsbelow10μM.InterfereswithPPARγcoactivator-1α(PGC-1α)/ERRα-dependentsignaling:inhibitsPGC-1αinductionofERRαandMAO-BgeneexpressionanddownregulatestheconstitutivetranscriptionalactivityofERRαinnumerouscelllines.
TechnicalData
| M.Wt | 596.42 |
| Formula | C23H13F9N4O3S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 725247-18-7 |
| PubChemID | 6918788 |
| InChIKey | HQFNFOOGGLSBBT-AWNIVKPZSA-N |
| Smiles | O=C(NC3=NN=C(C(F)(F)F)S3)/C(C#N)=C/C(C=C2OC)=CC=C2OCC1=C(C(F)(F)F)C=C(C(F)(F)F)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.96 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight596.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.68mL | 8.38mL | 16.77mL |
| 5mM | 0.34mL | 1.68mL | 3.35mL |
| 10mM | 0.17mL | 0.84mL | 1.68mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |
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