BiologicalActivity
FunctionallyselectivemuscarinicM1receptoragonist(EC50valuesare0.3,5,42,52and92.5nMatM1,M3,M5,M4andM2receptorsrespectively).Displaysacomplexpharmacologicalprofile:reversIBLeandwash-resistantbinding,resultinginfullagonistactivityatM1;delayedwash-resistantpartialagonistactivityatM2;anddelayedwash-resistantfullagonistactivityatM4.Exhibitsantipsychoticactivity,andimprovescognitivedeficitsandbehavioraldisturbancesinAlzheimer'sdiseaseandschizophrenia.
CompoundLibraries
XanomelineoxalateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 371.46 |
| Formula | C14H23N3OS.C2H2O4 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 141064-23-5 |
| PubChemID | 18920248 |
| InChIKey | ZJOUESNWCLASJP-UHFFFAOYSA-N |
| Smiles | CCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.15 | 100 | |
| ethanol | 9.29 | 25 | |
| water | 3.71 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.46mL | 26.92mL |
| 5mM | 0.54mL | 2.69mL | 5.38mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
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