BiologicalActivity
C-Terminalfragmentofxenin,aneurotensin-likepeptide;modulatespancreaticinsulinandglucagonsecretion/effects.Stimulatesbasalandarginine-inducedinsulinsecretionandpotentiatestheinsulinresponsetoglucose(EC50=0.16nM).Alsopotentiatesarginine-andcarbachol-inducedglucagonsecretioninasomatostatin-independentmanner.
TechnicalData
| M.Wt | 1046.28 |
| Formula | C51H79N15O9 |
| Sequence | HPKRPWIL |
| Storage | Desiccateat-20°C |
| CASNumber | 117442-28-1 |
| PubChemID | 90488740 |
| InChIKey | QNDRYLNMRDPBTI-OBOKMFOZSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1046.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.96mL | 4.78mL | 9.56mL |
| 5mM | 0.19mL | 0.96mL | 1.91mL |
| 10mM | 0.1mL | 0.48mL | 0.96mL |
| 50mM | 0.02mL | 0.1mL | 0.19mL |
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