BiologicalActivity
Highaffinityandselective5-HT6agonist(Ki=2.2nM).Displays60-foldselectivityoverother5-HTandmonoaminereceptors.Increasesfiringrateof5-HTneurons.Modifiessleepandwakefulnessprofilesfollowingdirectinjectionsintothedorsalraphenucleus,invivo.Orallybioavailable.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc
TechnicalData
| M.Wt | 470.91 |
| Formula | C15H13ClN4O2S2.C2H2O4 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1883548-85-3 |
| PubChemID | 121513871 |
| InChIKey | KAFVDFYVWBASDD-UHFFFAOYSA-N |
| Smiles | NCCC2=CN(S(C3=C(Cl)N=C4N3C=CS4)(=O)=O)C1=CC=CC=C12.O=C(O)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.09 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight470.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.12mL | 10.62mL | 21.24mL |
| 5mM | 0.42mL | 2.12mL | 4.25mL |
| 10mM | 0.21mL | 1.06mL | 2.12mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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