BiologicalActivity
Selectiveestrogenreceptormodulator(SERM)thatdisplaysselectivityforERαoverERβ(Kivaluesare0.09and11.31nMrespectively)andnocross-reactivitywithmineralocorticoid,glucocorticoid,androgenandprogesteronereceptors.ActsasanagoNISTintheboneandantagonistinreproductivetissue.Suppressesestrogen-stimulatedproliferationofER-positivehumanbreastcancerMCF-7andT47Dcells.
CompoundLibraries
Y134isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 472.6 |
| Formula | C28H28N2O3S |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 849662-80-2 |
| PubChemID | 11784736 |
| InChIKey | LQEOPHGPHCWOAC-UHFFFAOYSA-N |
| Smiles | CC(C)N1CCN(CC1)C1=CC=C(C=C1)C(=O)C1=C(SC2=CC(O)=CC=C12)C1=CC=C(O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.26 | 100 | |
| ethanol | 47.26 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight472.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.12mL | 10.58mL | 21.16mL |
| 5mM | 0.42mL | 2.12mL | 4.23mL |
| 10mM | 0.21mL | 1.06mL | 2.12mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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