BiologicalActivity
Novel,selectiveinhibitorofinterleukin-5(IL-5)(IC50=0.45-1mM).InhibitsIL-5-prolongedeosinophilsurvivalandIL-5-inducedtyrosinephosphorylationofJAK2withoutinhibitingGM-CSF-mediatedeffects.Inhibitsantigen-inducedeosinophilandlymphocyterecruitmentinratairwaysinvivo,withoutaffectingperipheralbloodorbonemarrowleukocytes.
LicensingInformation
SoldwiththepermissionofAstellasPharmaInc.
TechnicalData
| M.Wt | 359.43 |
| Formula | C22H21N3O2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 163769-88-8 |
| PubChemID | 1103147 |
| InChIKey | HIXSPVQXXDULHS-UHFFFAOYSA-N |
| Smiles | COC1=CC2=C(C=C1OC)C1=CC3=NC4=CC=CC=C4N=C3N1C(C)(C)C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.97 | 50 | |
| ethanol | 8.99 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight359.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.78mL | 13.91mL | 27.82mL |
| 5mM | 0.56mL | 2.78mL | 5.56mL |
| 10mM | 0.28mL | 1.39mL | 2.78mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
© 2005- 苏州蚂蚁淘生物科技有限公司 版权所有。
苏ICP备17049038号-11
苏公网安备 32059002001627号
声明：本网站部分产品受外界条件影响（包含但不限于进口国出口国政策限制等因素），无法提供销售服务，下单后，会由客服人员联系厂家确认后另行通知。部分危险品无法清关，请勿下单
我要提问
您的问题将推送给已购用户，TA们将会为你解答。