BiologicalActivity
ApotentandselectivecompetitiveantagonistfortheangiotensinIItype1(AT1)receptor.Displaces[125I]-angiotensinIIbindingwithanIC50valueof3.8nMinguineapigadrenalglandmembranes.Orallyactive,andismorepotentandlonger-actingthantheprototypeAT1antagonist,losartan.
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
TechnicalData
| M.Wt | 474.99 |
| Formula | C26H26N6O.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 146709-78-6 |
| PubChemID | 9826191 |
| InChIKey | NAGGAAHTUXEGFG-UHFFFAOYSA-N |
| Smiles | Cl.CCC1=CC2=C(CCC(=O)N2CC2=CC=C(C=C2)C2=CC=CC=C2C2=NN=NN2)C(CC)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 11.87 | 25 | |
| water | 4.75 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight474.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.11mL | 10.53mL | 21.05mL |
| 5mM | 0.42mL | 2.11mL | 4.21mL |
| 10mM | 0.21mL | 1.05mL | 2.11mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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