Tocris抗体，试剂，血清，细胞 Tocris配体,Tocris/TASP 0390325/5729/50/50 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/TASP 0390325/5729/50/50 mg

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Tocris

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5729/50

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4000-520-616

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Description:PotentandselectiveV_1BreceptorantagoNIST;orallybioavailable

ChemicalName:2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamidehydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveV_1Breceptorantagonist(IC₅₀=2.22nMforratpituitaryreceptor).Exhibitsnosignificantaffinityfor85otherreceptors,ionchannelsandtransportersat10μM,includingV_1AandV₂.IncreasesACTHlevelsinrats.Orallybioavailable.Antidepressantandanxiolytic.

TechnicalData

M.Wt	554.44
Formula	C₂₅H₂₉ClFN₅O₄.HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1642187-96-9
PubChemID	86765292
InChIKey	NUIXGNLBPARAII-UHFFFAOYSA-N
Smiles	O=C(NC(C)C)CN1C(C2=CC(OCCCN3CCOCC3)=CN=C2N=C1C4=CC=C(F)C(Cl)=C4)=O.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	55.44	100
	water	55.44	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight554.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.8mL	9.02mL	18.04mL
5mM	0.36mL	1.8mL	3.61mL
10mM	0.18mL	0.9mL	1.8mL
50mM	0.04mL	0.18mL	0.36mL

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