BiologicalActivity
HighaffinityhistamineH3receptorantagonist(Kivaluesare21.7and22.7nMforratandhumanH3receptors,respectively).ExhibitsselectivityforhumanH3overH1,H2andH4receptors(Kivaluesare2940,14400and>10000nMrespectively).Showntoreduceweightinadiet-inducedobesitymodel.
TechnicalData
| M.Wt | 422.39 |
| Formula | C22H27N3O.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1049740-32-0 |
| PubChemID | 16078942 |
| InChIKey | XFPYVTSGYYMTFS-GHVWMZMZSA-N |
| Smiles | CN(C)[C@H](CC3)CN3CCCOC1=CC=C(C2=CC=C(C#N)C=C2)C=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.45 | 20 | |
| water | 42.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight422.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.84mL | 23.67mL |
| 5mM | 0.47mL | 2.37mL | 4.73mL |
| 10mM | 0.24mL | 1.18mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
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