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Tocris/A 80426 mesylate/2341/10/10 mg

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Tocris

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2341/10

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4000-520-616

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Description:Highaffinityα₂antagoNIST.Also5-HTuptakeinhibitor

ChemicalName:N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanaminemesylate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highaffinityα₂-adrenoceptorantagonistandselective5-HTuptakeinhibitor(K_ivaluesare2.01and3.77nMrespectively).DisplayslowaffinityatavarietyofstructurallyhomologousGPCRs.

TechnicalData

M.Wt	445.57
Formula	C₂₃H₂₇NO₂.CH₃SO₃H
Storage	Desiccateat+4°C
Purity	≥98%(HPLC)
CASNumber	152148-64-6
PubChemID	10366248
InChIKey	RKQPEIGWZATOHW-FYZYNONXSA-N
Smiles	COC1=C2C([C@H](CN(CCC3=CC(OC=C4)=C4C=C3)C)CCC2)=CC=C1.CS(=O)(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	44.56	100
	water	4.46	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight445.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.24mL	11.22mL	22.44mL
5mM	0.45mL	2.24mL	4.49mL
10mM	0.22mL	1.12mL	2.24mL
50mM	0.04mL	0.22mL	0.45mL

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