BiologicalActivity
PotentandselectiveS1P5agonist(EC50valuesare4.1and5.7nMincAMPandGTPγSassays,respectively).Exhibits60-foldselectivityoverS1P1,and>1,600-foldselectivityoverS1P2-4,andapanelof129kinasesand79receptors.Improvesblood-brainbarrierintegrityinvitroandreversesage-relatedcognitivedeclineinvivo.Orallyavailable.
TechnicalData
| M.Wt | 366.24 |
| Formula | C18H17Cl2NO3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1240308-45-5 |
| PubChemID | 46872626 |
| InChIKey | WAAWETUDFSIYSD-UHFFFAOYSA-N |
| Smiles | ClC1=C(Cl)C=C(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 36.62 | 100 | |
| 1eq.NaOH | 36.62 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight366.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.73mL | 13.65mL | 27.3mL |
| 5mM | 0.55mL | 2.73mL | 5.46mL |
| 10mM | 0.27mL | 1.37mL | 2.73mL |
| 50mM | 0.05mL | 0.27mL | 0.55mL |
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