BiologicalActivity
PotenthistamineH4receptorantagonist(pKivaluesare8.24and8.47inhumanandratH4receptorsrespectively).Displays162-fold,620-fold,and>1600-foldselectivityoverhumanH3,H1andH2receptors.Blockszymosan-inducedneutrophilrefluxandattenuatesthermalhypersensitivityinvivo(ED50=42μmol/kg,ip).
CompoundLibraries
A987306isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 327.42 |
| Formula | C18H25N5O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1082954-71-9 |
| PubChemID | 25109291 |
| InChIKey | DJKJVWJQAVGLHJ-YPMHNXCESA-N |
| Smiles | NC3=NC1=C(C(N4CCNCC4)=N3)CCC2=C1[C@@](CCCC5)([H])[C@@]5([H])O2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.74 | 100 | |
| ethanol | 32.74 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight327.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.05mL | 15.27mL | 30.54mL |
| 5mM | 0.61mL | 3.05mL | 6.11mL |
| 10mM | 0.31mL | 1.53mL | 3.05mL |
| 50mM | 0.06mL | 0.31mL | 0.61mL |
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