BiologicalActivity
PotentandselectiveERβagonist(EC50valuesare6and5000nMforERβandERαrespectively).ExhibitsgenderselectiveneuroprotectiveeffectsinamaleratmodelofParkinson'sdisease.DecreasesAβlevelsincombinationwithACP-105inaratmodelofAlzheimer'sdisease.
CompoundLibraries
AC186isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 306.32 |
| Formula | C18H17F3O |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1421854-16-1 |
| PubChemID | 71245042 |
| InChIKey | HSMUKSLNDJOZQG-UHFFFAOYSA-N |
| Smiles | FC1(F)CCC(C2=C(F)C=CC=C2)(C3=CC=C(O)C=C3)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight306.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.26mL | 16.32mL | 32.65mL |
| 5mM | 0.65mL | 3.26mL | 6.53mL |
| 10mM | 0.33mL | 1.63mL | 3.26mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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ProductDatasheets
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