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Description:SelectivemGlu5receptorantagoNIST
ChemicalName:3-Amino-6-chloro-5-dimethylamino-N-2-pyridinylpyrazinecarboxamidehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
AntagonistatthemGlu5receptor(Ki=295nM).InhibitshumanmGlu5receptor-mediatedcalciumfluxwithanIC50of134nM.
TechnicalData
| M.Wt | 329.19 |
| Formula | C12H13ClN6O.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 37804-11-8 |
| PubChemID | 16759168 |
| InChIKey | CXIHLPLRTFPHKX-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)C1=C(Cl)N=C(C(=O)NC2=CN=CC=C2)C(N)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.92 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight329.19.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.04mL | 15.19mL | 30.38mL |
| 5mM | 0.61mL | 3.04mL | 6.08mL |
| 10mM | 0.3mL | 1.52mL | 3.04mL |
| 50mM | 0.06mL | 0.3mL | 0.61mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet

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