Tocris化合物筛选文库 TOCRIS 4372-10MG,Tocris/ACT 335827/4983/50/50 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/ACT 335827/4983/50/50 mg

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Tocris

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4983/50

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4000-520-616

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Description:PotentandselectiveOX₁antagoNIST

ChemicalName:(aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveorexinOX₁receptorantagonist(K_bvaluesare41and560nMforOX₁andOX₂receptorsrespectively).Elicitsanxiolyticeffectsinvivo.Brainpenetrantandorallyavailable.

TechnicalData

M.Wt	518.64
Formula	C₃₁H₃₈N₂O₅
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1354039-86-3
PubChemID	54765113
InChIKey	HXHOBPVRRPCTLG-SETSBSEESA-N
Smiles	O=C(NC(C)C)[C@@H]([C@]4=CC=CC=C4)N2CCC1=CC(OC)=C(OC)C=C1[C@@H]2CC3=CC(OC)=C(OC)C=C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	51.86	100
	ethanol	51.86	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight518.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.93mL	9.64mL	19.28mL
5mM	0.39mL	1.93mL	3.86mL
10mM	0.19mL	0.96mL	1.93mL
50mM	0.04mL	0.19mL	0.39mL

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PreparingStockSolutions

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