Tocris型号参数规格 Tocris多肽,Tocris/(±)-ADX 71743/5715/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/(±)-ADX 71743/5715/10/10 mg

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Tocris

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5715/10

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4000-520-616

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Description:NegativeallostericmodulatoratmGlu₇;brainpenetrant

ChemicalName:6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

NegativeallostericmodulatoratmGlu₇(IC₅₀=300nM).Blockshighfrequency-inducedLTPatSC-CA1synapsesinhippocampalslicesinvitro.Increasesevokedexcitatorypostsynapticcurrents(eEPSCs)inmice.Brainpenetrant.

TechnicalData

M.Wt	269.34
Formula	C₁₇H₁₉NO₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	53391766
InChIKey	CPKZCQHJDFSOJT-UHFFFAOYSA-N
Smiles	CC(C=C1C)=CC=C1C(CC2=C3N=C(CC)O2)CC3=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	26.93	100
	ethanol	26.93	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight269.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.71mL	18.56mL	37.13mL
5mM	0.74mL	3.71mL	7.43mL
10mM	0.37mL	1.86mL	3.71mL
50mM	0.07mL	0.37mL	0.74mL

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BiologicalActivity

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SolubilityData

PreparingStockSolutions

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