BiologicalActivity
Asubtype-selectiveligandfortheα1B-adrenoceptor.ThepKivaluesforbindingtoratfibroblastcellmembranesexpressingα1B(hamster),α1A(bovine)andα1D(rat)are7.1,5.59,and5.68respectively.Appearstobenon-selectivebetweenα1subtypesandα2receptorsinsmoothmusclepreparations.
TechnicalData
| M.Wt | 374.91 |
| Formula | C21H26N2O2.HCl |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 179388-65-9 |
| PubChemID | 9907616 |
| InChIKey | WWHGFIXWBLHHQB-UHFFFAOYSA-N |
| Smiles | Cl.OC(COC1=C(C=CC=C1)C1=CC=CC=C1)CC(=N)N1CCCCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto25mMinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight374.91.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.67mL | 13.34mL | 26.67mL |
| 5mM | 0.53mL | 2.67mL | 5.33mL |
| 10mM | 0.27mL | 1.33mL | 2.67mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
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