BiologicalActivity
ArelativelypotentandselectiveantagonistofgroupImetabotropicglutamatereceptors(mGlu1a),havingnoeffectongroupII(mGlu2)orgroupIII(mGlu4)receptorsexpressedindividuallyinbabyhamsterkidneycells.Hasnoeffectonionotropicglutamatereceptors.Centrallyactivefollowingsystemicadministrationinvivo.
TechnicalData
| M.Wt | 221.21 |
| Formula | C11H11NO4 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 168560-79-0 |
| PubChemID | 2071 |
| InChIKey | LSTPKMWNRWCNLS-UHFFFAOYSA-N |
| Smiles | NC2(C(O)=O)C1=CC=C(C(O)=O)C=C1CC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq.NaOH | 22.12 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight221.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.52mL | 22.6mL | 45.21mL |
| 5mM | 0.9mL | 4.52mL | 9.04mL |
| 10mM | 0.45mL | 2.26mL | 4.52mL |
| 50mM | 0.09mL | 0.45mL | 0.9mL |
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