BiologicalActivity
AnanalogofretinoicacidthatactsasaselectiveRARαagonist(EC50valuesare0.3,8.6and13nMforRARα,RARβandRARγrespectively).SignificantlyinducesIL-4,IL-5andIL-13andinhibitsIL-12andIFNγsynthesis,andinducescelldifferentiationwithover7timestheactivityofretinoicacidinvitro.
CompoundLibraries
AM580isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 351.44 |
| Formula | C22H25NO3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 102121-60-8 |
| PubChemID | 2126 |
| InChIKey | SZWKGOZKRMMLAJ-UHFFFAOYSA-N |
| Smiles | CC1(C)CCC(C)(C)C2=CC(=CC=C12)C(=O)NC1=CC=C(C=C1)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.57 | 50 | |
| ethanol | 35.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight351.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.85mL | 14.23mL | 28.45mL |
| 5mM | 0.57mL | 2.85mL | 5.69mL |
| 10mM | 0.28mL | 1.42mL | 2.85mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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