Tocris公司代理生物计划 Tocris多肽,Tocris/AM 80/3507/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/AM 80/3507/10/10 mg

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Tocris

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3507/10

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4000-520-616

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Description:RARαagoNIST;anticancer

AlternativeNames:Tamibarotene

ChemicalName:4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoicacid

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Retinoicacidreceptorα(RARα)agonistthatinducesdifferentiation(ED₅₀=0.79nM)andapoptosisofHL-60cellsinvitro.Exhibitsantiproliferativeeffectsagainstavarietyofhumantumorcellslines(meanvaluesof35,40and60%growthinhibitionat0.1,1and10μMrespectively)anddisplaysanticanceractivityagainstacutepromyelocyticleukemiainvivo.

TechnicalData

M.Wt	351.44
Formula	C₂₂H₂₅NO₃
Storage	StoreatRT
Purity	≥99%(HPLC)
CASNumber	94497-51-5
PubChemID	108143
InChIKey	MUTNCGKQJGXKEM-UHFFFAOYSA-N
Smiles	O=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1.1eq.NaOH	35.14	100
	DMSO	17.57	50
	ethanol	17.57	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight351.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.85mL	14.23mL	28.45mL
5mM	0.57mL	2.85mL	5.69mL
10mM	0.28mL	1.42mL	2.85mL
50mM	0.06mL	0.28mL	0.57mL

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BiologicalActivity

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