BiologicalActivity
HighlyselectiveCXCR4chemokinereceptorantagonist(IC50valuesare0.02-0.13and>25μMforCXCR4andallotherchemokinereceptorsrespectively).SwitchesinflammatoryresponsesfromTh4toTh1typeandreducesairwayhyperresponsivenessinamousemodelofasthma.PotentlyinhibitsHIV-1andHIV-2replicationinvitro(EC50=4-35nM)andmobilizeshematopoieticstemcellsinvivo.
TechnicalData
| M.Wt | 794.48 |
| Formula | C28H54N8.8HCl |
| Storage | Desiccateat-20°C |
| CASNumber | 155148-31-5 |
| PubChemID | 65014 |
| InChIKey | UEUPDYPUTTUXLJ-UHFFFAOYSA-N |
| Smiles | C1(CN3CCCNCCNCCCNCC3)=CC=C(CN2CCCNCCNCCCNCC2)C=C1.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 79.45 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight794.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.26mL | 6.29mL | 12.59mL |
| 5mM | 0.25mL | 1.26mL | 2.52mL |
| 10mM | 0.13mL | 0.63mL | 1.26mL |
| 50mM | 0.03mL | 0.13mL | 0.25mL |
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