BiologicalActivity
Potent,selectiveCXCR4antagonist;exhibits8-foldhigheraffinitythanAMD3100(Cat.No.3299).InhibitsSDF-1α-ligandbinding(Ki=41.7nM).PotentlyinhibitsHIVcellentryinvitro;causesleukocytosisandmobilizeshaematopoieticstemcellsinvivo.
CompoundLibraries
AMD3465hexahydrobromideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 896.07 |
| Formula | C24H38N6.6HBr |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 185991-07-5 |
| PubChemID | 9897616 |
| InChIKey | ARHBIBDGWDRBJH-UHFFFAOYSA-N |
| Smiles | C1(CN3CCCNCCNCCCNCC3)=CC=C(CNCC2=NC=CC=C2)C=C1.Br.Br.Br.Br.Br.Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.4 | 25 | |
| water | 44.8 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight896.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.12mL | 5.58mL | 11.16mL |
| 5mM | 0.22mL | 1.12mL | 2.23mL |
| 10mM | 0.11mL | 0.56mL | 1.12mL |
| 50mM | 0.02mL | 0.11mL | 0.22mL |
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